synthesis, antinociceptive, antiinflammatory and antiepileptic evaluation of some novel indeno[1, 2-b] quinoxalin-11-ylidenamines

a series of novel indeno[1, 2-b]quinoxalin-11-ylidenamines 2-9 have been synthesized via condensation of indane[1, 2-b]quinoxalin-11-one (1) with various primary aromatic amines in presence of acoh for 3 h. compound 1 was synthesized by condensation of indane-1,2,3-trione with benzene-1,2-diamine in presence of acoh. the synthesized compounds were characterized by ir, 1h-nmr, mass spectra and elemental analysis. compounds 2-9 were screened for anti-nociceptive, anti-inflammatory and antiepileptic activity by acoh induced writhing method, carrageenan induced paw edema method and maximal electroshock induced convulsion method respectively. out of the eight synthesized compounds, indeno[1, 2-b]quinoxalin-11-ylidine (4-nitrophenyl)amine (3) exhibited promising anti-inflammatory activity and anti-nociceptive activity. n-(2,4-dinitrophenyl)-n' -(indeno[1,2-b]quinoxalin-11-ylidene)hydrazine (7) showed promising anti-inflammatory activity, anti-nociceptive activity, and antiepileptic activity, whereas n4-indeno[1, 2-b]quinoxalin-11-ylidene biphenyl-4,4'-diamine (8) showed promising anti-inflammatory activity.